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  Acetaminophen/butalbital/caffeine is used in the treatment of headache and belongs to the drug class analgesic combinations. Risk cannot be ruled out during pregnancy.

Acetaminophen/butalbital/caffeine 325 mg / 50 mg / 40 mg is not a controlled substance under the Controlled Substances Act (CSA). Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches. Butalbital belongs to the group of medicines called barbiturates.

Barbiturates act in the central nervous system (CNS) to produce their effects. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time.

But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage. When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly.

However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Caffeine is a CNS stimulant that is used with pain relievers to increase their effect. It has also been used for migraine headaches.

However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it. This medicine is available only with your doctor’s prescription.

Key Points to Understanding Fioricet

Fioricet is a combination prescription medication used to treat migraines and tension headaches. Keep the following key points in mind regarding Fioricet:

  • Fioricet includes butalbital, acetaminophen and caffeine
  • Fioricet is a controlled substance and should be taken exactly as prescribed
  • As a depressant, Fioricet can have side effects like feeling sluggish or drowsiness as the body adjusts to the medication. In rare cases, side effects can be more severe.
  • Fioricet can interact with other drugs and health conditions and you should speak to a doctor if you are taking other medications, have any other health conditions or are pregnant
  • Fioricet has some addictive qualities
  • Misusing Fioricet can be dangerous or deadly

What you should know before you take Fioricet ?

  • Do not overuse Fioricet because you may become addicted to it and have difficulty stopping it.
  • Over-use of Fioricet can also result in a medication-overuse headache (also known as a rebound headache) which occurs when analgesics are taken too frequently to relieve a headache.
  • Never share your Fioricet with anybody else.
  • May be administered without regards to food; although food may decrease any reported stomach upset.
  • If you have been taking Fioricet regularly, or if you think you have become addicted to it, talk to your doctor about slowly withdrawing it, as sudden withdrawal may precipitate a withdrawal syndrome (symptoms include anxiety, dizziness, hallucinations, muscle twitching, nausea, seizures, sleeplessness, or tremor).
  • Fioricet can cause sedation and affect your ability to drive or operate machinery.
  • Do not drink more than two alcoholic drinks a day if you are a man or one alcoholic drink per day if you are women and taking Fioricet.
  • Talk to your doctor if you have any side effects of concern. Seek urgent medical advice if you develop an allergic-type reaction (difficulty breathing or swallowing, rash, or facial swelling) soon after taking Fioricet.
  • Not recommended for women who are pregnant or breastfeeding.
  • Fioricet contains acetaminophen which may be “hidden” in other cough/cold medicines. The total dose of acetaminophen from any source should not exceed 4000mg per day (24 hours).
  • Talk to your doctor or pharmacist before taking any other medications or natural products with Fioricet as it can interact with a large number of drugs.

Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches.

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Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

Fioricet Chemical Structure
Fioricet Chemical Structure

When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Caffeine is a CNS stimulant that is used with pain relievers to increase their effect. It has also been used for migraine headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it. This medicine is available only with your doctor’s prescription. This product is available in the following dosage forms:

      • Tablet
      • Capsule
      • Solution

What should you know before you take Fioricet ?

Blue Fioricet
Blue Fioricet

Before taking Fioricet, tell your doctor or pharmacist if you are allergic to acetaminophen, caffeine, or butalbital; or to other barbiturates (such as phenobarbital) or xanthine derivatives (such as theophylline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe breathing problems (such as bronchopneumonia), a certain enzyme disorder (porphyria), liver disease, kidney disease, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), mental/mood disorders, abdominal/stomach problems (such as stomach ulcer). Do not use Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. You should not use Fioricet if you are allergic to acetaminophen, butalbital, or caffeine, if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. To make sure Fioricet is safe for you, tell your doctor if you have:

      • liver disease, cirrhosis, a history of alcoholism or drug addiction, or if you drink more than 3 alcoholic beverages per day;
      • kidney disease;
      • asthma, sleep apnea, or other breathing disorder;
      • stomach ulcer or bleeding;
      • a history of skin rash caused by any medication;
      • a history of mental illness or suicidal thoughts; or
      • if you use medicine to prevent blood clots.

It is not known whether Fioricet will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant. This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Liquid products may contain alcohol, sugar and/or aspartame. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely. Before having surgery or certain medical procedures (such as a heart stress test or a procedure to restore a normal heart rhythm if you have an unusually fast heartbeat), tell your doctor or dentist that you use this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially drowsiness and trouble falling asleep. These side effects can increase the risk of falling. During pregnancy, this medication should be used only when clearly needed. Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication for an extended time may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, seizures, or diarrhea. Tell your doctor right away if you notice any of these symptoms in your newborn. This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of butalbital, acetaminophen, and caffeine combination in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of butalbital, acetaminophen, and caffeine combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving butalbital, acetaminophen, and caffeine combination.

Pregnancy

Information about this butalbital-acetaminophen-and-caffeine-oral-route
  Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethal dose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days. Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient’s regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.

  •  

Fioricet Addiction

As with many medications, when taken over a long period of time or in high doses, the body can come to depend on the drug to function normally. Misusing Fioricet can result in dependence and addiction and can pose serious risks to health. Signs of a Fioricet addiction can include drug-seeking behavior, doctor-shopping or pretending to lose Fioricet prescriptions to get access to more. Fioricet has addictive qualities, and it’s important to watch for signs of addiction when using this medication. If you are misusing or addicted to Fioricet, getting off the drug is the first step of recovery. There are different types of treatments available that can address Fioricet addiction. Treatment can also include therapy and skill building, which can address the underlying reasons for abusing Fioricet.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Drug dependence, or history of or
  • Weakened physical condition—Use with caution. May increase risk for more serious side effects.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Porphyria (an enzyme problem)—Should not be used in patients with this condition.
  • Stomach problems—Use with caution. May make these conditions worse.

Fioricet Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:

More common

  1. Lightheadedness
  2. shortness of breath

Incidence not known

  1. Abdominal or stomach pain
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, or loosening of the skin
  5. blood in the urine or stools
  6. blurred vision
  7. change in the frequency of urination or amount of urine
  8. chills
  9. cough
  10. diarrhea
  11. difficulty with breathing
  12. difficulty with swallowing
  13. dizziness
  14. drowsiness
  15. dry mouth
  16. fainting
  17. fast, pounding, or irregular heartbeat or pulse
  18. flushed or dry skin
  19. fruit-like breath odor
  20. hives, itching, or skin rash
  21. increased hunger
  22. increased thirst
  23. increased urination
  24. joint or muscle pain
  25. loss of appetite
  26. nausea or vomiting
  27. pinpoint red spots on the skin
  28. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  29. red skin lesions, often with a purple center
  30. red, irritated eyes
  31. seizures
  32. shakiness in the legs, arms, hands, or feet
  33. sore throat
  34. sores, ulcers, or white spots in the mouth or on the lips
  35. sweating
  36. swelling of the feet or lower legs
  37. tightness in the chest
  38. trembling or shaking of the hands or feet
  39. troubled breathing
  40. unexplained weight loss
  41. unusual bleeding or bruising
  42. unusual tiredness or weakness
  43. weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Confusion as to time, place, or person
  2. dark urine
  3. difficult or painful urination
  4. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  5. fever
  6. general feeling of discomfort or illness
  7. hallucinations
  8. headache
  9. holding false beliefs that cannot be changed by fact
  10. increased sweating
  11. irregular, fast or slow, or shallow breathing
  12. light-colored stools
  13. loss of appetite
  14. pale or blue lips, fingernails, or skin
  15. restlessness
  16. sudden decrease in the amount of urine
  17. sweating
  18. trouble sleeping
  19. unpleasant breath odor
  20. unusual excitement, nervousness, or restlessness
  21. vomiting of blood
  22. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Relaxed and calm
  2. sleepiness

Incidence not known

    1. Anxiety
    2. bloated
    3. constipation
    4. continuing ringing or buzzing or other unexplained noise in the ears
    5. depression
    6. earache
    7. excess air or gas in the stomach or intestines
    8. false or unusual sense of well-being
    9. full feeling
    10. hearing loss
    11. heartburn
    12. heavy eyelids
    13. high energy
    14. hot spells
    15. hyperventilation
    16. irritability
    17. numbness
    18. pain in the leg
    19. passing gas
    20. sluggishness
    21. stuffy nose
    22. tingling sensation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. We do not suggest you to take Fioricet or Gabapentinfor a long time, you need go to your local health professional to treat your pain without prescription. We think exercising is the best way to relieve your pain. Exercising is a very good methods. Exercising can enhance your immune system and increase your muscle strength and make your nerve strong. You can also take some nutrition from food.  You can try USANA Products here to make you more health and young and get rid of your pain.

What should I avoid while taking Fioricet?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. While you are taking this medication, avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice.

The Symptoms of Fioricet Withdrawal

In most cases, Fioricet withdrawal lasts anywhere from 8 hours to three days after the last dose. Withdrawal is the biggest obstacle to overcoming dependence on Fioricet, which is why rehab centers provide detox programs so that people can safely undergo the withdrawal cycle without the risk of relapse. It is best to undergo withdrawal under medical supervision because some withdrawal symptoms are dangerous. Rebound headaches are the most common symptoms of Fioricet withdrawal. Other symptoms of withdrawal include:

      • Anxiety
      • Dizziness
      • Insomnia
      • Muscle spasms
      • Nausea and vomiting
      • Rapid emotional changes
      • Seizures (in rare cases)
      • Tremors
      • Weakness

What are the Symptoms of a Fioricet Overdose?

While butalbital is the addictive ingredient in Fioricet, acetaminophen is the ingredient which is liable to cause an overdose. Unfortunately, people who misuse Fioricet as a recreational drug or as a way to suppress withdrawal are most likely to suffer an overdose. When a person overdoses on Fioricet, the acetaminophen will damage their liver. In severe cases, an overdose can even provoke fatal liver failure. For this reason, it is dangerous to take Fioricet together with another medication which contains acetaminophen because it increases the risk of overdose and death. Furthermore, drinking alcohol while taking Fioricet may also inflict liver damage. A Fioricet overdose is a medical emergency, so it’s important to know the symptoms. An overdose on Fioricet and all other forms of liver failure cause jaundice, the yellowing of the skin and eyes. Other symptoms of an overdose include:

  • Confusion
  • Convulsions and seizures
  • Fainting
  • Irregular heartbeat
  • Lack of appetite
  • Nausea and vomiting
  • Restlessness
  • Stomach pain
  • Sweating
  • Tremors

Who Uses Fioricet?

People who use Fioricet are primarily people who suffer from tension headaches or migraines. However, a small portion of people using Fioricet may be using them to treat neck pain or any other kinds of headaches. Women are more likely than men to be diagnosed with chronic migraines and therefore are more likely to receive a prescription of Fioricet. People who receive treatment for migraine are often slightly older and report more severe symptoms.

Fioricet Statistics

Approximately 6% of people who suffer from migraines use a barbiturate combination medication. Although it is often not the first treatment option, millions of people are prescribed Fioricet or a similar drug to manage their headache or migraine symptoms.

Fioricet addictive ?

One of the key active ingredients responsible for the so-called Fioricet high is butalbital. Butalbital is a barbiturate that’s considered short-to-intermediate acting, and it can relieve symptoms of anxiety, reduce pain, relax muscles and act as a sedative. There are many neuropsychological effects of butalbital, some of which aren’t clearly understood to this day.  
 
The belief is that the Fioricet high is caused by the fact that butalbital can increase the inhibition neurotransmitters in the brain called GABA. It can bind to certain receptor sites and ultimately central nervous system activity is depressed. This can lead to what feels like a buzz or to some people possibly a high. So what does a Fioricet high feel like?  It is from the online Internet but Fioricet will not get you high because fioricet contains 325mg acetaminophen. The max dosage per day of acetaminophen may vary from 3,000 mg to 4,000 mg but do not take more than 4,000 mg in a 24-hour period. The max dosage of Fioricet is six tablet. Every tablet of fioricet only contains 40mg butalbital. The max dosage of butalbital you take is 240 mg per day.
 
According to rxlist, “the average daily dose for the barbiturate addict is usually about 1500 mg”, it is not possible for a patient who takes fioricet to get high. “Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethal dose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days.
 
Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient’s regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.” For the most part, it’s likely to feel similar to other central nervous system depressant effects.
 
There is some evidence pointing to the fact that taking Fioricet can feel similar to the effects of drinking alcohol, particularly when the prescription drug is taken at higher levels.
 
The following are some of the common experiences that people say come along with a Fioricet high:
  • Fioricet can reduce anxiety and some people with anxiety disorders may take it for this reason, although this is not what it’s approved for. There is the potential for Fioricet to decrease feelings of anxiety even when it’s taken at a normal dose, and this is because of the impact of butalbital on GABA. For some people, a Fioricet high is actually just equated with a reduction in anxiety.
  • Depersonalization may be another effect of the so-called Fioricet high, although this isn’t necessarily something people find pleasant. It can lead to feelings of confusion and sluggishness, and this is one of the reasons Fioricet isn’t frequently used
  • Drowsiness and sedation may also be side effects of a Fioricet high, particularly when it’s taken in larger amounts. While Fioricet has a stimulant component which is caffeine when larger doses are taken the central nervous system depressant effects may override the stimulant effects.
  • Some people may obtain a sense of euphoria when taking Fioricet, although it’s not as pronounced as what would occur with something like prescription opioids. As with most other drugs, if someone does experience euphoria with a Fioricet high, it’s likely to dissipate after using the drug a few times as they build a tolerance.
  • While not everyone who takes Fioricet says they experience euphoria, some people say that it does improve their mood. This can be because of the GABA-related effects of butalbital, but also the inclusion of the acetaminophen and the caffeine. There’s also the element of stimulation that can occur with caffeine, so some people may feel this is a Fioricet high when they experience it.
  • Lightheadedness and dizziness are common side effects of Fioricet, and these may also be symptoms that people associate with a Fioricet high.
  • One of the primary reasons people will abuse Fioricet and take high doses is to achieve relaxation, which occurs because of the slowdown of the central nervous system. People who take this drug may feel relaxed and also tranquil. Some of this is because of the loosening up of muscles the drug can stimulate.
Not everyone will associate the use of this drug with the Fioricet high. Some of the factors that determine whether or not a person will experience a Fioricet high can include the dosage they take and their tolerance. Newer users may be more likely to experience what they would describe as the Fioricet high. Other factors that could influence this include the specific formulation of the drug and whether or not other substances are taken with it.
 

Fioricet Drug Interactions

Fioricet Interaction
Fioricet Interaction

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

      • Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

        • Alfentanil
        • Alprazolam
        • Amobarbital
        • Anisindione
        • Aprobarbital
        • Butabarbital
        • Carisoprodol
        • Chloral Hydrate
        • Chlordiazepoxide
        • Chlorzoxazone
        • Clarithromycin
        • Clonazepam
        • Clorazepate
        • Dantrolene
        • Darunavir
        • Diazepam
        • Dicumarol
        • Doxorubicin
        • Doxorubicin Hydrochloride Liposome
        • Esketamine
        • Estazolam
        • Ethchlorvynol
        • Etonogestrel
        • Flunitrazepam
        • Flurazepam
        • Halazepam
        • Imatinib
        • Iobenguane I 131
        • Isoniazid
        • Ketazolam
        • Lorazepam
        • Lormetazepam
        • Medazepam
        • Mephenesin
        • Mephobarbital
        • Meprobamate
        • Metaxalone
        • Methocarbamol
        • Methohexital
        • Midazolam
        • Nifedipine
        • Nitrazepam
        • Oxazepam
        • Peginterferon Alfa-2b
        • Pentobarbital
        • Phenindione
        • Phenobarbital
        • Phenprocoumon
        • Piperaquine
        • Pixantrone
        • Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
        • Prazepam
        • Primidone
        • Quazepam
        • Secobarbital
        • Sodium Oxybate
        • Temazepam
        • Thiopental
        • Triazolam
        • Ulipristal

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

        • Acenocoumarol
        • Cannabis
        • Carbamazepine
        • Fosphenytoin
        • Lixisenatide
        • Ospemifene
        • Phenytoin
        • Prednisone
        • Warfarin
        • Zidovudine

Other Prescription Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol
  • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Cabbage
  • Ethanol

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